The spindle assembly checkpoint pathway is an elegantly engineered surveillance system for protecting the cell from the adverse consequences of improper kinetochore-microtubule attachment.
Engineered Elegance: Generating the Wait Anaphase Signal Read More »
In a recent article, I discussed the astounding role of motor proteins in eukaryotic cell division. But this is just one of many incredible engineered features associated with mitosis. In this and a subsequent article, I will provide an overview of the elegant molecular mechanisms that underlie the spindle assembly checkpoint and discuss the implications of its dysfunction.
The Elegant Spindle Assembly Checkpoint Read More »